The short answer is no.
There’s a lot of study on this topic from the cybersecurity perspective. If you could create an undetectable virtualization layer then it would be used for real-world cyberattacks to steal money and the existence would be quickly noticed by security researchers (and future hardware would include changes to mitigate the vulnerability). It wouldn’t be used for creating aimbots for video games.
If you want to read into the technical details, this stackoverflow thread has a lot of links to various papers and articles on the topic: https://stackoverflow.com/questions/39533/how-to-identify-that-youre-running-under-a-vm
I use a desktop all day, every day (Arch, btw) because I work a tech job.
Android is based on Linux, true but it is hardly a desktop environment (and is mostly controlled by the carrier/Google from a privacy/enshittification perspective).
I think the Steamdeck is a better example. It’s converting console gamers into Linux desktop users and showing people that Linux gaming is very much possible.