As adrian mentioned, it can be hit and miss. On my lenovo laptop you can’t press space when holding up + left arrows. Many other key combinations with 5+ keys work. For platformers it’s a no go, so I’d always recommend something with N-key rollover to avoid weirdness.

Sure, but music production programs don’t work well under wine. Also, setting up linux for realtime music production is tough even without using wine.

You can definitely do production on wine, but recording instruments live isn’t feasible.